Objective To explore the application effect of advance care planning in hemodialysis patients.Methods A total of 80 hemodialysis patients who were treated in a tertiary hospital in Zhengzhou from October 2020 to June 2021 were selected as the research subjects. According to the random number table method,they were divided into a control group and an intervention group with 40 cases each. The intervention group was implemented with a 4-week advance care planning,and the control group received the routine care. The death attitude profile-revised scale,the Chinese version of the meaning in life questionnaire and the patient dignity inventory scale were used to compare the differences in death attitude,meaning of life and dignity between the 2 groups of patients.Results After the intervention,the patients in the intervention group changed their attitude toward death;the score of meaning of life was higher than that of the control group;the score of dignity was lower than that of the control group;the differences were statistically significant（P<0.05）.Conclusion Advance care planning can help hemodialysis patients change into a positive attitude toward death,increase the sense of meaning in life,and maintain the dignity of patients.